Ellen Pompeo, who began her role as Meredith Grey at age 35, is now 55 and has shifted to a recurring role after becoming a powerful voice for healthcare equity and diversity. Patrick Dempsey, 59, who famously played Derek āMcDreamyā Shepard, has transitioned into philanthropy while also surprising fans with a return to the show. Meanwhile, Katherine Heigl, who made waves as Izzie Stevens, has rebuilt her career after facing challenges, advocating fiercely for animal rights.