“The Facts of Life,” a beloved sitcom that debuted in 1979 as a spin-off of “Diff’rent Strokes,” is celebrating its 44th anniversary. The show, which featured an all-female lead cast, became a cultural touchstone for many viewers during the 70s and 80s. As fans reminisce about their favorite characters, curiosity grows about the cast’s current endeavors.

Charlotte Rae, who portrayed the nurturing Edna Garrett, left a significant mark on television history. After her departure from “The Facts of Life” in its eighth season, Rae continued to act, with her final appearance in “Ricky and the Flash” in 2015. Rae passed away in 2018 at the age of 92, leaving behind a legacy of warmth and wisdom.

Lisa Whelchel, known for her role as Blair Warner, has maintained a vibrant career, from her early days on “The New Mickey Mouse Club” to her Grammy-nominated music and bestselling parenting book. Whelchel also showcased her resilience on “Survivor Philippines,” finishing as the runner-up in 2012.

Mindy Cohn, who played Natalie Green, has remained active in the industry, participating in various film and television projects, including her role in “Casper” and advocating for the LGBT community following her breast cancer battle.

George Clooney, who appeared as handyman George Burnett, achieved remarkable fame as a Hollywood superstar, winning two Academy Awards and welcoming twins with his wife, Amal.

The series also featured notable performances by Cloris Leachman, Nancy McKeon, and Kim Fields, each continuing to carve their paths in entertainment. Leachman, who took over as Beverly Ann Stickle, passed away in 2021, while McKeon and Fields have remained active in acting, with recent roles in holiday films.

As the cast members reflect on their shared history, they exemplify how time enriches their stories, both on and off-screen. “The Facts of Life” endures as a testament to friendship, growth, and the complexities of life, with each cast member contributing to its lasting legacy.