Among the most notable losses is John Wayne, whose Oscar-winning portrayal of Rooster Cogburn cemented him as a Hollywood legend. Wayne passed away from stomach cancer in 1979, leaving behind a legacy that continues to influence generations. Dennis Hopper, who played the ill-fated outlaw Moon, battled personal demons throughout his life and succumbed to prostate cancer in 2010, a stark reminder of the chaos that often surrounded his brilliance.